What is the HOMOGENTISIC ACID?

HOMOGENTISIC ACID is off-white to tan crystals or crystalline powder, while it's Molecular Formula is C8H8 O4. off-white to tan crystals or crystalline powder Homogentisic acid may be used as an analytical reference standard for the quantification of the analyte in the following:Urine matrices using reversed-phase liquid chromatography tandem mass spectrometry (LC-MS/MS).Strawberry tree honey samples using reversed phase-high performance liquid chromatography (RP-HPLC) and ion chromatography (IC).It may also be used as an internal standard for the determination of ascorbic acid (AA) and uric acid (UA) in human plasma samples using high-pressure liquid chromatography–electrochemical detection (HPLC–ECD).

What is the CAS number for HOMOGENTISIC ACID?

The CAS number of HOMOGENTISIC ACID is 451-13-8.

What is HOMOGENTISIC ACID (451-13-8) used for?

Homogentisic acid (HGA) is an intermediate formed during the catabolism of phenylalanine and tyrosine. It is an off-white to tan crystalline substance that occurs naturally in plants and is found in the urine of individuals with alkaptonuria, a metabolic disorder characterized by high levels of HGA due to the deficiency of the enzyme homogentisic acid oxidase.InChI:InChI=1/C8H8O4/c9-6-1-2-7(10)5(3-6)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)/p-1

What is the HOMOGENTISIC ACID?

HOMOGENTISIC ACID is off-white to tan crystals or crystalline powder, while it's Molecular Formula is C8H8 O4. off-white to tan crystals or crystalline powder Homogentisic acid may be used as an analytical reference standard for the quantification of the analyte in the following:Urine matrices using reversed-phase liquid chromatography tandem mass spectrometry (LC-MS/MS).Strawberry tree honey samples using reversed phase-high performance liquid chromatography (RP-HPLC) and ion chromatography (IC).It may also be used as an internal standard for the determination of ascorbic acid (AA) and uric acid (UA) in human plasma samples using high-pressure liquid chromatography–electrochemical detection (HPLC–ECD).

What is the CAS number for HOMOGENTISIC ACID?

The CAS number of HOMOGENTISIC ACID is 451-13-8.

What is HOMOGENTISIC ACID (451-13-8) used for?

Homogentisic acid (HGA) is an intermediate formed during the catabolism of phenylalanine and tyrosine. It is an off-white to tan crystalline substance that occurs naturally in plants and is found in the urine of individuals with alkaptonuria, a metabolic disorder characterized by high levels of HGA due to the deficiency of the enzyme homogentisic acid oxidase.InChI:InChI=1/C8H8O4/c9-6-1-2-7(10)5(3-6)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)/p-1

HOMOGENTISIC ACID 451-13-8 with purity >99% Low price in stock

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HOMOGENTISIC ACID

Product Name HOMOGENTISIC ACID
cas 451-13-8
purity 99%

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HOMOGENTISIC ACID 451-13-8 with purity >99% Low price in stock

Molecular Formula: C8H8 O4
Molecular Weight: 168.149
Appearance/Colour: off-white to tan crystals or crystalline powder
Vapor Pressure: 1.71E-08mmHg at 25°C
Melting Point: 150-152 °C(lit.)
Refractive Index: 1.5090 (estimate)
Boiling Point: 439.3°Cat760mmHg
PKA: 4.4(at 25℃)
Flash Point: 233.6°C
PSA： 77.76000
Density: 1.478g/cm³
LogP: 0.72490

HOMOGENTISIC ACID(Cas 451-13-8) Usage

Purification Methods	Crystallise homogentisic acid from EtOH/CHCl3 or H2O (solubility is 85% at 25o). [Beilstein 10 IV 1506.]
General Description	Homogentisic acid (HGA) is an intermediate formed during the catabolism of phenylalanine and tyrosine. Alkaptonuria, a metabolic disorder, is characterized by high levels of HGA in serum and urine due to the deficiency of the enzyme homogentisic acid oxidase, which is involved in the degradation of HGA.

InChI:InChI=1/C8H8O4/c9-6-1-2-7(10)5(3-6)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)/p-1

451-13-8 Relevant articles

The structure of 4-hydroxylphenylpyruvate dioxygenase complexed with 4-hydroxylphenylpyruvic acid reveals an unexpected inhibition mechanism

Wang, Xiaoning,Lin, Hongyan,Liu, Junjun,Zhao, Xinyun,Chen, Xi,Yang, Wenchao,Yang, Guangfu,Zhan, Chang-guo

, p. 1920 - 1924 (2021)

4-Hydroxyphenylpyruvate dioxygenase (HPP...

Initial studies on the substrate specificity of soluble recombinant 4- hydroxyphenylpyruvate dioxygenase from rat liver

Crouch,Baldwin,Lee,MacKinnon,Zhang

, p. 1503 - 1506 (1996)

The molecular cloning and expression of ...

Toward a high added value compound 3, 4-dihydroxyphenylacetic acid by electrochemical conversion of phenylacetic acid

Trabelsi, Souhel Kallel,Dridi Gargouri, Olfa,Gargouri, Boutheina,Abdelhèdi, Ridha,Bouaziz, Mohamed

, p. 370 - 376 (2015/05/27)

Abstract The development of the effectiv...

Intermediate partitioning kinetic isotope effects for the NIH shift of 4-hydroxyphenylpyruvate dioxygenase and the hydroxylation reaction of hydroxymandelate synthase reveal mechanistic complexity

Shah, Dhara D.,Conrad, John A.,Moran, Graham R.

, p. 6097 - 6107 (2013/09/23)

4-Hydroxyphenylpyruvate dioxygenase (HPP...

Phytotoxic effects of selected N-benzyl-benzoylhydroxamic acid metallo-oxygenase inhibitors: Investigation into mechanism of action

Sergeant, Martin J.,Harrison, Peter J.,Jenkins, Robert,Moran, Graham R.,Bugg, Timothy D. H.,Thompson, Andrew J.

, p. 3461 - 3465 (2013/11/06)

Treatment of Arabidopsis thaliana with 1...

451-13-8 Process route

: 156-39-8
4-hydroxyphenylpiruvic acid

: 156-38-7
4-hydroxyphenylacetate

: 55604-87-0
(4-oxo-2,5-cyclohexadien-1-yl)acetic acid

: 451-13-8
homogentisic acid

: 13244-75-2
(S)-α,4-dihydroxy-benzeneacetic acid

Conditions

Conditions	Yield
With oxygen; iron(II) sulfate; In aq. phosphate buffer; at 25 ℃; pH=7; Enzymatic reaction;	47 %Chromat. 19 %Chromat. 15 %Chromat. 20 %Chromat.

: 156-39-8
4-hydroxyphenylpiruvic acid

: 156-38-7
4-hydroxyphenylacetate

: 55604-87-0
(4-oxo-2,5-cyclohexadien-1-yl)acetic acid

: 451-13-8
homogentisic acid

Conditions

Conditions	Yield
With oxygen; iron(II) sulfate; In aq. phosphate buffer; at 25 ℃; pH=7; Reagent/catalyst; Kinetics; Enzymatic reaction;	8.4 %Chromat. 45 %Chromat. 46.5 %Chromat.